BIO002 Evaluation of osteogenic effect by different phyestrogens in osteoblasts culture derived from mesenchymal stem cells

Abstract

Menopause is caused by the failure of ovarian hormones production and can produce unfavorable changes in lipid, glucose and insulin metabolism, in the coagulation/fibrinolysis system, as well as bone loss are some of its consequences. One of the current concerns is the relationship between the decrease in estrogen production and bone mass loss, which is considered a major risk factor for the development of osteoporosis in women. Osteoporosis is currently considered a worldwide public health problem and it is estimated that by 2030, more than one billion and 200 million women will be menopausal. One of the ways to treat menopause symptoms and decrease the chance of someone to develop osteoporosis is the use of the Hormone Replacement Therapy (HRT). However, this therapy has brought some risks to the health of some groups of women, especially those with a history of thromboembolic diseases and breast cancer in their families, and the use of phytoestrogens such as isoflavones is an alternative to the traditional treatment. Isoflavones are found mainly in soybeans (Glycine max), red clover (Trifolium pratense), Cimicifuga racemosa (of American origin) and rye.