FTOX050 Preliminary studies and biochemical characterization of bradykinin-potentiating peptides from Lachesis muta venom.

Abstract

Bradykinin-potentiating peptides (BPPs) are widely distributed in venoms from many species as pit vipers and scorpions. They act directly at the renin-angiotensin-aldosterone system (RAAS), preventing the release of angiotensin II and degradation of bradykinin by inhibiting the angiotensin-converting enzyme. The isolation and biochemical characterization of BPPs from pit vipers venoms are important to the development of specific drugs for the control of hypertension in humans. Pit vipers from genus Lachesis are known as the biggest venomous animals in Latin America. Because of their length, they are able to inject a large dose of venom into their victims. Therefore, the bite can lead the victim to death, due to complications induced by venom toxins that present coagulant, hemorrhagic, neurotoxic and inflammatory activities.