TY - JOUR AU - das Neves, Rogério Coutinho AU - Gomes Andrade, Rayanny AU - Alexandre Carollo, Carlos AU - Galdi Boaretto, Amanda AU - Kipnis, Andre AU - Paula Junqueira- Kipnis, Ana PY - 2019/11/07 Y2 - 2024/03/28 TI - Hyptis brevipes AND Paullinia pinnata EXTRACTS AND THEIR FRACTIONS PRESENTING ACTIVITY AGAINST Mycobacterium abscessus subsp. massiliense JF - Revista de Patologia Tropical / Journal of Tropical Pathology JA - Rev Patol Trop VL - 48 IS - 3 SE - ARTIGOS ORIGINAIS / ORIGINAL ARTICLES DO - 10.5216/rpt.v48i3.58993 UR - https://revistas.ufg.br/iptsp/article/view/58993 SP - 148-160 AB - <p>Medicinal plants are of great interest for the discovery of new biomolecules with diversified&nbsp;effects. Over the last decade different outbreaks caused by Mycobacterium abscessus&nbsp;subsp. massiliense have been reported, evidencing it as an important emerging pathogen&nbsp;in underdeveloped countries. This study investigated the antimycobacterial activity of six&nbsp;Brazilian medicinal plant extracts and their fractions. Hyptis brevipes, Tocoyena formosa,&nbsp;Randia armata, Paullinia pinnata, Lafoensia pacari and Anadenanthera colubrina were&nbsp;evaluated against M. a. massiliense. Total extracts from the medicinal plants H. brevipes, T.&nbsp;formosa, P. pinnata and L. pacari presented a minimal bactericidal concentration of 1 mg/mL. After fractioning, the ethanolic fractions from H. brevipes and P. pinnata presented&nbsp;bactericidal activity, and the ethyl acetate fraction from H. brevipes and T. formosa presented&nbsp;antimycobacterial action. The best bactericidal function of all plant fractions was the ethanolic,&nbsp;which contained rutin and rosmarinic acid that were shown to have microbicidal activity.</p><p><strong>KEY WORDS</strong>: Mycobacterium abscessus; medicinal plants; Brazilian medicinal plants; HPLC<br>and biodiversity.</p> ER -