@article{Vieira de Souza_Benamor Teixeira_Fragoso da Silveira Gouvêa_Milnor_de Lima Filho_de Souza Borges Quintana_Cavalcanti Rolla_2021, place={Goiânia}, title={Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection}, volume={50}, url={https://revistas.ufg.br/iptsp/article/view/68574}, DOI={10.5216/rpt.v50i3.68574}, abstractNote={<p>Tuberculosis is the leading cause of death amongst adults with human immunodeficiency virus (HIV) infection. The lifetime risk of tuberculosis disease for a person with latent infection is estimated at 5-10% with most cases occurring within five years of initial  infection. The World Health Organization recommends isoniazid preventive therapy (IPT) for latent tuberculosis treatment, amongst other strategies. The aim was to assess tuberculosis  incidence, survival (free of tuberculosis) and associated factors in HIV-positive patients. IPT was offered to participants with a positive (≥5mm) tuberculin skin test. Participants were followed from February 2003-December 2016. Kaplan-Meier was used for survival analysis. Variables with p-value ≤ 0.2 in the univariate analysis entered into the multivariate Cox-Model, keeping those with p-value ≤ 0.05. The 95% confidence interval of incidence of tuberculosis was estimated using Poisson distribution. One hundred nineteen patients completed the IPT and were followed for a median duration of 110.7 months (IQR 93.1-121.0). The probability of developing tuberculosis (10 years post-IPT) was 5.4%. Tuberculosis incidence was 0.58/100 patient/years (CI 95% 0.213-1.264). IPT over 6 months provided long-term protection against tuberculosis. AIDS-defining illness was the only statistically significant variable (HR=5.67) in the multivariate model.<br />KEY WORDS: Latent tuberculosis; HIV; isoniazid; survival analysis.</p>}, number={3}, journal={Revista de Patologia Tropical / Journal of Tropical Pathology}, author={Vieira de Souza, Claudia Teresa and Benamor Teixeira, Maria de Lourdes and Fragoso da Silveira Gouvêa, Maria Isabel and Milnor, Jacob and de Lima Filho , Jose Berilo and de Souza Borges Quintana, Marcel and Cavalcanti Rolla, Valéria}, year={2021}, month={set.}, pages={201–211} }