The effects of an exercise program on the response of CD4+ and CD8+ T lymphocytes in people living with HIV/AIDS (PLWHA): a systematic review

Autores

  • Ilva Lana Balieiro Capela Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil https://orcid.org/0000-0003-1891-708X
  • Luciana Santiago de Oliveira Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil https://orcid.org/0000-0002-2421-0649
  • Andressa Karoline Pinto de Lima Ribeiro Federal University of Pará, João de Barros Barreto University Hospital, Graduate Program in Diabetes Care and Clinical Research, Belém, Pará, Brazil https://orcid.org/0000-0002-7981-938X
  • Antonio Carlos Rosário Vallinoto Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil https://orcid.org/0000-0003-1135-6507
  • Izaura Maria Vieira Cayres Vallinoto Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil https://orcid.org/0000-0003-1408-8384

DOI:

https://doi.org/10.5216/rpt.v52i3.75637

Resumo

People living with HIV and AIDS (PLWHA) have decreased functional capacity, muscle strength and quality of life. Furthermore, HIV/AIDS can cause some adverse effects and long-term problems, such as sarcopenia and some peripheral neuropathies. A common practice among the healthy population that helps to modify these risk factors is to practice of some kind of exercise, such as aerobic and resistance exercises. The objective of this review is to assess the possible effects of exercise on the increase in CD4+ and/or CD8+ T lymphocytes among PLWHA. The LILACS, IBECS, PubMed/MEDLINE, Cochrane Library, SciELO, PEDro, ScienceDirect and Bireme databases were systematically searched for randomized controlled trials. The following descriptors were used in the search in English, Portuguese and Spanish: HIV, physical functional performance, resistance training, and aerobic exercise. The methodological quality of the studies was evaluated using the PEDro scale. The data were read, analyzed, extracted, and synthesized. Of the 3,319 studies consulted, only five met the inclusion criteria. A synthesis of the five selected studies was performed, all of which were randomized controlled trials. It was concluded that aerobic and/or resistance exercise protocols have a positive effect on immunity (CD4+ and/or CD8+ T lymphocytes and TNF-α) and on the metabolic/ biochemical profile of PLWHA.

KEY WORDS: HIV; AIDS; CD4; CD8; exercise.

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Biografia do Autor

Antonio Carlos Rosário Vallinoto, Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil

and Federal University of Pará, Institute of Biological Sciences, Laboratory of Virology, Belém, Pará, Brazil

Izaura Maria Vieira Cayres Vallinoto, Federal University of Pará, Institute of Biological Sciences, Graduate Program in Biology of Infectious and Parasitic Agents, Belém, Pará, Brazil

and Federal University of Pará, Institute of Biological Sciences, Laboratory of Virology, Belém, Pará, Brazil

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Publicado

2023-10-18

Como Citar

BALIEIRO CAPELA, I. L.; SANTIAGO DE OLIVEIRA, L.; PINTO DE LIMA RIBEIRO, A. K.; ROSÁRIO VALLINOTO, A. C.; VIEIRA CAYRES VALLINOTO, I. M. The effects of an exercise program on the response of CD4+ and CD8+ T lymphocytes in people living with HIV/AIDS (PLWHA): a systematic review . Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 52, n. 3, p. 159–176, 2023. DOI: 10.5216/rpt.v52i3.75637. Disponível em: https://revistas.ufg.br/iptsp/article/view/75637. Acesso em: 13 jul. 2024.

Edição

Seção

REVISÃO / REVIEW