Evolution of the prevalence and antimicrobial resistance among Escherichia coli isolated as a cause of infection in patients admitted to a iv-level hospital in Lima, Peru

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DOI:

https://doi.org/10.5216/rpt.v51i3.74360

Resumo

The levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum β-lactamases (ESBLs) were determined. Overall, 9,918 microorganisms were isolated as a cause of infection. Of these 3,016 (30.4%) were E. coli, with 1,770 (59%), 992 (33%) and 254 (8%), from the Medicine and the Surgery Departments and the Intensive Care Unit (ICU), respectively. There was a significant increase (p=0.0002) of E. coli throughout considered periods. The isolates presented high levels of resistance (>60%) to cephalosporins, ciprofloxacin and cotrimoxazole, being only susceptible to imipenem (0.3% of resistance) and tigecycline. Overall the analysis of evolution of antimicrobial resistance showed that resistance to cephalosporins and amikacin significantly increased, while, the ones of piperacillintazobactam, cotrimoxazole and gentamicin had significantly decreased. Nevertheless, the ICU isolates showed an inverse scenario for cephalosporins. These findings agree with an increase of ESBLs on the Medicine (56% to 66%; p<0.0001) and on the Surgery (54% to 62%; p=0.0197) departments, with a parallel decrease in the ICU (76% to 68%). In summary, high levels of antimicrobial resistance have been reported among E. coli, with worrisome levels of ESBL. A continuous surveillance of antimicrobial resistance levels in the area is needed.

KEY WORDS: Escherichia coli; antimicrobial resistance; cephalosporins

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Biografia do Autor

Wilfredo Flores-Paredes*, Hospital Nacional Guillermo Almenara Irigoyen, Servicio de Microbiología, Lima, Peru

*Wilfredo Flores-Paredes and Nestor Luque contributed equally to this work

Nestor Luque*, Universidad Peruana Union (UPeU), Escuela de Medicina Humana, Facultad de Ciencias de la Salud, Lima, Peru

*Wilfredo Flores-Paredes and Nestor Luque contributed equally to this work

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Publicado

2022-10-19

Como Citar

FLORES-PAREDES*, W.; LUQUE*, N.; ALBORNOZ, R.; ROJAS, N.; ESPINOZA, M.; RUIZ, J.; J PONS, M. Evolution of the prevalence and antimicrobial resistance among Escherichia coli isolated as a cause of infection in patients admitted to a iv-level hospital in Lima, Peru. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 51, n. 3, p. 197–212, 2022. DOI: 10.5216/rpt.v51i3.74360. Disponível em: https://revistas.ufg.br/iptsp/article/view/74360. Acesso em: 29 maio. 2024.

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Seção

ARTIGOS ORIGINAIS / ORIGINAL ARTICLES