Epidemiological evaluation of patients submitted to the galactomannan test with suspected invasive aspergillosis

Autores

DOI:

https://doi.org/10.5216/rpt.v50i2.69589

Resumo

Invasive aspergillosis (IA) increases dramatically when there is potential risk in many patient groups, in particular with hematological malignancies. The purpose of the study was to trace the epidemiological profile of patients who underwent galactomannan test by ELISA with suspected IA and to determine the factors that contribute to the development of the disease. We evaluated 264 patients who underwent galactomannan test with suspected IA from 2013 to 2015.The clinical-epidemiological characteristics were determined using descriptive statistics. The variables were evaluated using the chi-square test (χ2) and the G-test, with p-value considered significant below 0.05. According to the classification for IA by the European Organization for Research and Treatment of Cancer, the disease was considered proven in 7.3%, defined by positive culture for the fungus, 6.4% as probable through detection of galactomannan and the presence of pulmonary infiltrates and 5.1% as possible by radiological alterations suggestive of IA and negative galactomannan test. The mortality rate was 31.6% of all patients and 61.3% for proven / probable / possible IA indicating that the disease was significantly associated with the risk of death. According to these result indications and considering the high mortality rate caused by the development of IA, as well as the fact that early therapy promotes significant improvement in the patients’ prognosis, we conclude that the detection of galactomannan may be considered an effective method to aid the identification of IA. 

KEY WORDS: Invasive pulmonary aspergillosis; neutropenia; enzyme-liked immunosorbent assay; ELISA test searching for Aspergillus; galactomannan.

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Biografia do Autor

Hellen da Silva Cintra de Paula, Hospital Araújo Jorge, Laboratório de Biologia Tumoral, Goiânia, Goiás, Brazil

Hospital Araújo Jorge, Associação de Combate ao Câncer de Goiás, Laboratório de Biologia Tumoral, Goiânia, Goiás, Brazil

Cesar Sam Tiago Vilanova-Costa, Hospital Araújo Jorge, Laboratório de Biologia Tumoral, Goiânia, Goiás, Brazil

Hospital Araújo Jorge, Associação de Combate ao Câncer de Goiás, Laboratório de Biologia Tumoral, Goiânia, Brazil

Vera Aparecida Saddi, Pontifícia Universidade Católica de Goiás, Programa Pós-Graduação Ciências Ambientais e Saúde, Goiânia, Goiás, Brazil

1. Pontifícia Universidade Católica de Goiás, Programa Pós-Graduação Ciências Ambientais e Saúde, Goiânia, Goiás, Brazil.

2. Hospital Araújo Jorge, Associação de Combate ao Câncer de Goiás, Laboratório de Biologia Tumoral, Goiânia, Brazil.

3. Pontifícia Universidade Católica de Goiás, Escola de Ciências Medicas, Farmacêuticas e Biomédicas, Goiânia, Goiás, Brazil

Antonio Marcio Teodoro Cordeiro Silva, Pontifícia Universidade Católica de Goiás, Programa Pós-Graduação Ciências Ambientais e Saúde, Goiânia, Goiás, Brazil

1. Pontifícia Universidade Católica de Goiás, Programa Pós-Graduação Ciências Ambientais e Saúde, Goiânia, Goiás, Brazil.

2. Pontifícia Universidade Católica de Goiás, Escola de Ciências Medicas, Farmacêuticas e Biomédicas, Goiânia, Goiás, Brazil

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Publicado

07-07-2021

Como Citar

de Oliveira Cunha, D., Andreia Bernardes Leão Cordeiro, J., da Silva Cintra de Paula, H., Silvestre Ataides, F., Sam Tiago Vilanova-Costa, C., Aparecida Saddi, V., & Marcio Teodoro Cordeiro Silva, A. (2021). Epidemiological evaluation of patients submitted to the galactomannan test with suspected invasive aspergillosis. Revista De Patologia Tropical / Journal of Tropical Pathology, 50(2), 107–119. https://doi.org/10.5216/rpt.v50i2.69589

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ARTIGOS ORIGINAIS / ORIGINAL ARTICLES