Effects of multiple doses of simvastatin and artesunate monotherapy on SCHISTOSOMA MANSONI adult worms during infection in hyperlidemic mice

Autores

  • Alba Cristina Miranda de Barros Alencar Fluminense Federal University, Medical School, Department of Pathology, Rio de Janeiro, Rio de Janeiro, Brazil, acmbalencar@id.uff.br https://orcid.org/0000-0002-0473-4381
  • Thais Silva dos Santos State University of Rio de Janeiro, Faculty of Medical Sciences, Department of Microbiology, Immunology and Parasitology Romero, Rio de Janeiro,  Rio de Janeiro, Brazil, thaisilvaabio@gmail.com https://orcid.org/0000-0002-0233-6240
  • Luciana Brandao-Bezerra State University of Rio de Janeiro, Faculty of Medical Sciences, Biomedical Center, Department of Microbiology, Immunology and Parasitology Romero,  Rio de Janeiro, Rio de Janeiro, Brazil, lulithomas@gmail.com https://orcid.org/0000-0001-6729-8487
  • Eduardo Jose Lopes-Torres State University of Rio de JaneiroState University of Rio de Janeiro, Faculty of Medical Sciences, Biomedical Center, Department of Microbiology, Immunology and Parasitology Romero,  Rio de Janeiro, Rio de Janeiro, Brazil, lopestorresej@gmail.com https://orcid.org/0000-0003-0206-3681
  • Jose Firmino Nogueira Neto State University of Rio de Janeiro, Faculty of Medical Science, Lipid Laboratory, Rio de Janeiro, Rio de Janeiro, Brazil, firminouerj@gmail.com https://orcid.org/0000-0002-5368-5248
  • Renata Heisler Neves State University of Rio de Janeiro, Faculty of Medical Sciences, Biomedical Center, Department of Microbiology, Immunology and Parasitology Romero,  Rio de Janeiro, Rio de Janeiro, Brazil, renataheisler@gmail.com https://orcid.org/0000-0002-5442-0030
  • Jose Roberto Machado Silva State University of Rio de JaneiroState University of Rio de Janeiro, Faculty of Medical Sciences, Biomedical Center, Department of Microbiology, Immunology and Parasitology Romero,  Rio de Janeiro, Rio de Janeiro, Brazil, jrmasilva@gmail.com https://orcid.org/0000-0003-3085-0228

DOI:

https://doi.org/10.5216/rpt.v50i1.67007

Resumo

A single dose of simvastatin and of artesunate monotherapy cause damage to the reproductive system of schistosomes as well as severe tegumental damage in male worms recovered from mice fed high-fat chow. This study aims to investigate whether treatment with multipledose regimes may offer more antischistosomal activity advantages than single daily dosing in mice fed high-fat chow. For this purpose, nine weeks post-infection, Swiss Webster mice were gavaged with simvastatin (200 mg/kg) or artesunate (300 mg/kg) for five consecutive days and euthanized two weeks post-treatment. Adult worms were analyzed using brightfield
microscopy, confocal microscopy and scanning electron microscopy, presenting damages caused by simvastatin and artesunate to the reproductive system of males and females as well as tegument alterations, including peeling, sloughing areas, loss of tubercles, tegumental bubbles and tegument rupture exposing subtegumental tissue. The overall findings in this study revealed the potential antischistosomal activity of simvastatin and artesunate against Schistosoma mansoni adult worms, in addition to showing that multiple doses of either monotherapy caused severe damage to the tegument.
KEY WORDS: Schistosoma mansoni; hyperlipidemia; simvastatin; artesunate; microscopy.

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Publicado

2021-03-08

Como Citar

ALENCAR, A. C. M. de . B.; SILVA DOS SANTOS, T.; BRANDAO-BEZERRA, L.; JOSE LOPES-TORRES, E.; FIRMINO NOGUEIRA NETO , J.; HEISLER NEVES, R. .; ROBERTO MACHADO SILVA, J. Effects of multiple doses of simvastatin and artesunate monotherapy on SCHISTOSOMA MANSONI adult worms during infection in hyperlidemic mice. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 50, n. 1, p. 21–39, 2021. DOI: 10.5216/rpt.v50i1.67007. Disponível em: https://revistas.ufg.br/iptsp/article/view/67007. Acesso em: 28 mar. 2024.

Edição

Seção

ARTIGOS ORIGINAIS / ORIGINAL ARTICLES