MULTICENTER STUDY OF CANDIDA SPECIES IN ORAL MUCOSA OF DIFFERENT PATIENTS: ANALYSIS OF 711 STRAINS AND LITERATURE REVIEW

Autores

  • Rennan Luiz Oliveira dos Santos University of São Paulo (USP), São Paulo, Brazil.
  • Luciana Silva Ruiz Instituto Adolfo Lutz
  • Marcos Ereno Auler University of Unicentro, Paraná, Brazil
  • Jorge Kleber Chavasco University of Alfenas, Minas Gerais, Brazil
  • Débora Moreira Medical School, USP, São Paulo, Brazil
  • Regina Teixeira Barbieri Ramos University of São Paulo (USP), São Paulo, Brazil
  • Bruna Rossini Lara Adolfo Lutz Institute, Bauru, São Paulo, Brazil
  • Claudete Rodrigues Paula University of São Paulo (USP), São Paulo, Brazil

DOI:

https://doi.org/10.5216/rpt.v49i2.63481

Resumo

This study aimed to identify Candida spp. collected from oral mucosa and maintained in culture collections, correlating the findings with the medical history of patients and comparing with data from the literature over the past five years. Seven hundred and eleven oral Candida spp. isolates, collected between 2013 and 2017,  were selected and identified using traditional and molecular methods. In addition, a literature review was performed with the key words: “Oral”, “Candida” and “Yeast”. Seven species of the genus Candida: were identified C. albicans (73.3%); C. tropicalis (9.3%); C. parapsilosis (8.2%); C. glabrata (3.9%); C. guilliermondii
(2.8%); C. krusei (1.7%) and C. lusitaniae (0.3%). The strains identified as C. albicans were submitted to molecular methods using specific primers and of these, 5.8% were identified as C. dubliniensis strains. The greatest diversity of strains was found in patients presenting no systemic diseases or HIV +, while the highest percentage of strains of Candida non-albicans were observed in cancer patients. This study reports a representative distribution of Candida species among individuals exhibiting distinct clinical conditions, in order to contribute to the design of future research on details of aspects involved in the infections caused by these
microorganisms. The correct identification of oral Candida strains contributes to a realistic epidemiological approach and future clinical protocols against these pathogens.
KEY WORDS: Candida; oral candidiasis; dentistry; yeasts; HIV; co-infection

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Biografia do Autor

Rennan Luiz Oliveira dos Santos, University of São Paulo (USP), São Paulo, Brazil.

Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.

Luciana Silva Ruiz, Instituto Adolfo Lutz

Adolfo Lutz Institute, Section of Biomedical Sciences, Mycology Laboratory, Bauru, São Paulo, Brazil.

Marcos Ereno Auler, University of Unicentro, Paraná, Brazil

Department of Clinical Analysis, University of Unicentro, Paraná, Brazil.

Jorge Kleber Chavasco, University of Alfenas, Minas Gerais, Brazil

Department of Microbiology and Immunology, University of Alfenas, Minas Gerais, Brazil.

Débora Moreira, Medical School, USP, São Paulo, Brazil

Department of Gynecology and Obstetrics, Medical School, USP, São Paulo, Brazil.

Regina Teixeira Barbieri Ramos, University of São Paulo (USP), São Paulo, Brazil

Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.

Bruna Rossini Lara, Adolfo Lutz Institute, Bauru, São Paulo, Brazil

1. Adolfo Lutz Institute, Section of Biomedical Sciences, Mycology Laboratory, Bauru, São Paulo, Brazil.

2. Institute of Biosciences, Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.

Claudete Rodrigues Paula, University of São Paulo (USP), São Paulo, Brazil

Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.

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Publicado

2020-07-19

Como Citar

LUIZ OLIVEIRA DOS SANTOS, R.; RUIZ, L. S.; ERENO AULER, M.; KLEBER CHAVASCO, J.; MOREIRA, D.; TEIXEIRA BARBIERI RAMOS, R.; ROSSINI LARA, B.; RODRIGUES PAULA, C. MULTICENTER STUDY OF CANDIDA SPECIES IN ORAL MUCOSA OF DIFFERENT PATIENTS: ANALYSIS OF 711 STRAINS AND LITERATURE REVIEW. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 49, n. 2, p. 105–119, 2020. DOI: 10.5216/rpt.v49i2.63481. Disponível em: https://revistas.ufg.br/iptsp/article/view/63481. Acesso em: 8 nov. 2024.

Edição

Seção

ARTIGOS ORIGINAIS / ORIGINAL ARTICLES