USE OF THE POLYMERASE CHAIN REACTION (PCR)FOR EARLY EVALUATION

Autores

  • Carlos Diego Lacunza
  • Olga Sánchez Negrete
  • María Celia Mora
  • Alejandro Uncos
  • María Asunción Segura
  • Néstor Del Castillo
  • María Isabel Garayzabal
  • Miguel Ángel Basombrío

DOI:

https://doi.org/10.5216/rpt.v35i3.1883

Resumo

Fourteen patients (age limits: 18-30) chronically infected with Trypanosoma cruzi and presenting positive blood PCR reactions, were submitted to etiological treatment with benznidazole, in Salta, Argentina. A control group of five patients of the same age and positive by PCR did not receive treatment. Post-treatment follow-up was performed with PCR and conventional serology. PCR became negative in 12/14 (85.7%) of the treated patients after six months follow up, compared to 1/5 (20%) in the control group (p = 0.01). All patients remained serologically positive after treatment. The reduction of PCR signals of infection after treatment may become an early evidence of cure in chronically infected young adult patients.

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Publicado

2007-10-17

Como Citar

LACUNZA, C. D.; NEGRETE, O. S.; MORA, M. C.; UNCOS, A.; SEGURA, M. A.; DEL CASTILLO, N.; GARAYZABAL, M. I.; BASOMBRÍO, M. Ángel. USE OF THE POLYMERASE CHAIN REACTION (PCR)FOR EARLY EVALUATION. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 35, n. 3, p. 227–232, 2007. DOI: 10.5216/rpt.v35i3.1883. Disponível em: https://revistas.ufg.br/iptsp/article/view/1883. Acesso em: 8 out. 2024.

Edição

Seção

ARTIGOS ORIGINAIS / ORIGINAL ARTICLES