USE OF THE POLYMERASE CHAIN REACTION (PCR)FOR EARLY EVALUATION

  • Carlos Diego Lacunza
  • Olga Sánchez Negrete
  • María Celia Mora
  • Alejandro Uncos
  • María Asunción Segura
  • Néstor Del Castillo
  • María Isabel Garayzabal
  • Miguel Ángel Basombrío

Abstract

Fourteen patients (age limits: 18-30) chronically infected with Trypanosoma cruzi and presenting positive blood PCR reactions, were submitted to etiological treatment with benznidazole, in Salta, Argentina. A control group of five patients of the same age and positive by PCR did not receive treatment. Post-treatment follow-up was performed with PCR and conventional serology. PCR became negative in 12/14 (85.7%) of the treated patients after six months follow up, compared to 1/5 (20%) in the control group (p = 0.01). All patients remained serologically positive after treatment. The reduction of PCR signals of infection after treatment may become an early evidence of cure in chronically infected young adult patients.

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Published
17-10-2007
How to Cite
Lacunza, C. D., Negrete, O. S., Mora, M. C., Uncos, A., Segura, M. A., Del Castillo, N., Garayzabal, M. I., & Basombrío, M. Ángel. (2007). USE OF THE POLYMERASE CHAIN REACTION (PCR)FOR EARLY EVALUATION. Revista De Patologia Tropical / Journal of Tropical Pathology, 35(3), 227-232. https://doi.org/10.5216/rpt.v35i3.1883
Section
ARTIGOS ORIGINAIS / ORIGINAL ARTICLES