BIO080 Oral melatonin administration and sexual hormones influences during the experimental chagas’ disease

Resumo

Chagas’disease is the clinical manifestation of the infection produced by the parasite Trypanosoma cruzi. It’s a zoonosis and the major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Melatonin is an indoleamine synthesized in the pineal gland and its physiological properties are not limited to neuroendocrine system in controlling circadian rhythms, several other actions have been discovered as increase innate and acquired immunity, however, very little is known about its influence on protozoan infections. Gender affects the different steps of an immune response. Exposure to various types of antigens, access to health promotion programs and health care, as well as prioritization of health needs and household resource allocation all affect the different response of females and males to immunologic challenges and it is necessary undertand the influences of immunological mechanisms in health and disease.