CM004 Evaluation of chiral stationary phases in the separation of the enantiomers of fexofenadine

Resumen

Fexofenadine is commercially available as a racemic mixture of two pharmacologically active enantiomers and it can be found under the trade name Allegra® D. Studies have shown that the pharmacokinetics of fexofenadine is enantioselective with a plasma concentration of R-fexofenadine greater than the S-isomer. In the literature, there are only a few reports of enantioselective separation of fexofenadine using HPLC columns based on cyclodextrins.