PNS027 Modulatory activity of flavonoids in production of reactive oxygen species from neutrophils of patients with rheumatoid arthritis

Resumen

Rheumatoid arthritis (RA) is a chronic disease characterized by synovial tissue inflammation, where neutrophils (PMN) are the most abundant cells and are important mediators of tissue destruction. Tissue damage in AR involves excessive production of reactive oxygen species (ROS) triggered by immune complexes (IC) and neutrophils interactions via receptors Fc?R and complement receptors (CR). Modulation of both the effector potential of these receptors and ROS generation may be relevant to the maintenance of body homeostasis. Compounds as flavonoids have been considered helpful to inhibit and/or modulate the oxidative damage associated with PMN.