CM003 Conductivity measurements to assess the effect of solvent on the dissociation of sodium salt of diclofenac

Abstract

The literature offers several methods to estimate the dissociation constants of drugs that are very little soluble in water, and for which this parameter is a property of great relevance. The pk values are used in drug dispensing problems and development of dosage forms and can also be used to predict which pH will provide an optimal bioavailability by maintained a certain ratio of ionized and unionized form of the drug. In addition, allows you to predict the solubility of drugs in water by a simple relation involving the pH of the solution and the concentration of the drug. Since most anti-inflammatory drugs are very little soluble in water, the dissociation constants of the values found in the literature were obtained in water mixtures with an organic solvent, especially an alcohol, to provide a suitable solubility.