PNS049 Gastroprotective activity of the extract and fractions from leaves of “couve” (Brassica oleracea var acephala DC) in chronic ulcer model

Abstract

Gastric ulcer is a major cause of morbidity and mortality between diseases of the digestive tract. The genesis of the disease is associated with an imbalance of endogenous protective agents and aggressors of the gastric mucosa. Brassica oleracea var. acephala DC is known in Brazil as “couve”, and is popularly used in the juice form for treatment of ulcers and gastritis. In a recent study, B. oleracea var. acephala showed significant gastroprotective activity by increase the pH and mucus production in the stomach. (Lemos et al. Journal of Ethnopharmacology 138: 503, 2011). Studies developed by our group have shown that the chloroform fraction (CF) and aqueous fraction (AF) contain metabolites which may be responsible for the antiulcer activity.