PNS037 Synthesis of New phenazine

Abstract

The phenazines are an important class of heterocyclic that have a wide spectrum of biological activity, such as antimalarial, antimicrobial and antitumor activity. The importance of this class is verified by more 6,000 phenazine compounds identified and reported during the past century. One way of obtaining phenazines is by synthesis from quinones. Methodologies have been previously described to obtain phenazines from quinones in good yields using solid phase synthesis or in solution of acetic acid. Quinones, such as 1,4-naphthoquinone, are largely employed in organic synthesis because of its potential as intermediate in the preparation of heterocycles and because of the different biological properties described in the literature. It has been reported that the addition of amines in the 2 position of 1,4-naphthoquinone also results in products with biological activity. In this context, this study synthesized a new phenazine in moderate yields which can be useful for pharmacological screenings.