BIO055 Study of the effector function of murine macrophages infected in vitro with Salmonella enteritidis

Abstract

Salmonella nontyphoidal is a major cause of foodborne illness in the world. The Enteritidis has being identified as the most common serovar and is responsible for gastroenteritis and even systemic infections. In developing countries, Enteritidis and Typhimurium Serovar cause invasive infections leading to death of young children with underlying diseases and also, death of adults infected with HIV [1]. These bacteria can proliferate within epithelial cells and non-activated macrophages, but by using specific mechanisms of pathogenicity island SPI2, they may persist also in activated macrophages, showing cytotoxic effects on these cells.