BIO044 Chemoprotective action of L-Selenomethionine in HepG2 cells: evaluation of stress genes expression induced by H2O2.

Abstract

Among the agents that have been analyzed for chemoprotective potential for cancer, the components of diet have been the best scores, with the adequate intake of certain foods having the property to protect the DNA and consequently prevent the development of several cancers. Such studies provide evidence that foods provide nutrients and bioactive substances that can alter gene expression. The antioxidant activity of selenium appears to be responsible for its effectiveness in treating diseases which have as their development process the oxidative stress. Due to these aspects, it have been growing interest in investigating the roles of different selenium compounds as a therapeutic agent in various chronic degenerative diseases, such as cancers.