FTOX015 Evaluation of uptake glutamate in cultures of retina cells in the presence of cunaniol.

Abstract

In 1968, Quilliam & Stables ictiotóxica showed activity in fish tank extracts derived from Clibadium sylvestre. Costa et al (2006) demonstrated the seizure activity in mice caused by ethanol extract of Clibadium surinamese, and that the substances causing majority of excitatory activity correspond to acetate and cunaniol cunaniol. However, the proconvulsant mechanisms remain unknown (Hamoy, 2002 and Costa et al, 2006). Thus we sought to evaluate the activity of cunaniol in vitro and determine possible changes in glutamate uptake in cultured retinal cells of chick embryo.