TFC029 Evaluation of emulsion solvent evaporation method as an approach to produce nanoparticles of Polycaprolactone containing ursolic acid

Abstract

Preliminary studies have shown that ursolic acid (UA), a natural compound, presents important pharmacological properties, such as trypanocidal activity. However, it has low water solubility, which reduces its bioavailability. Among the existing drug delivery systems, polymeric nanoparticles (NPs) play a central role, due to their ability to sustain or control the release of drugs. Moreover, nanocoated systems are distinguished by high drug encapsulation efficiency, protection from degradation, and less likely to cause irritation due to their polymeric coating.