IDENTIFICATION OF DESVENLAFAXINE, THE MAJOR ACTIVE METABOLITE OF VENLAFAXINE, IN EXTENDED-RELEASE CAPSULES

Autores

  • Wilsione Jose Carneiro UFG
  • Carolina Horta Andrade UFG

DOI:

https://doi.org/10.5216/ref.v7i1.9594

Palavras-chave:

Degradation studies, extended-release capsules, desvenlafaxine, ESI-MS/MS.

Resumo

In this work, we describe the identification of desvenlafaxine in extended release capsules of venlafaxine (VEN) in acid degradation studies. We developed a stability indicating reverse-phase HPLC method and validated for the analysis of VEN in pharmaceutical formulation. The HPLC method was linear over the range of 0.45-1.05 mg/ml (r2=0.999). The RSD values for intra- and inter-day precision studies showed good results (RSD < 2%) and accuracy was greater than 99%. The degradation studies in acidic media for 24 h showed two additional peaks, which were further identified by ESI-MS/MS as the desvenlafaxine and the dehydration product of venlafaxine. Furthermore, desvenlafaxine is the major active metabolite of venlafaxine and has recently been approved for treatment of major depressive disorder. 10.5216/ref.v7i1.9594

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Publicado

2010-04-13

Como Citar

CARNEIRO, W. J.; ANDRADE, C. H. IDENTIFICATION OF DESVENLAFAXINE, THE MAJOR ACTIVE METABOLITE OF VENLAFAXINE, IN EXTENDED-RELEASE CAPSULES. Revista Eletrônica de Farmácia, Goiânia, v. 7, n. 1, p. 15, 2010. DOI: 10.5216/ref.v7i1.9594. Disponível em: https://revistas.ufg.br/REF/article/view/9594. Acesso em: 23 maio. 2024.

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