CM004 Evaluation of chiral stationary phases in the separation of the enantiomers of fexofenadine

Autores

  • Gisele Maria Metta
  • Anderson Rodrigo Moraes de Oliveira

Resumo

Fexofenadine is commercially available as a racemic mixture of two pharmacologically active enantiomers and it can be found under the trade name Allegra® D. Studies have shown that the pharmacokinetics of fexofenadine is enantioselective with a plasma concentration of R-fexofenadine greater than the S-isomer. In the literature, there are only a few reports of enantioselective separation of fexofenadine using HPLC columns based on cyclodextrins.

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Publicado

2012-12-28

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METTA, G. M.; DE OLIVEIRA, A. R. M. CM004 Evaluation of chiral stationary phases in the separation of the enantiomers of fexofenadine. Revista Eletrônica de Farmácia, Goiânia, v. 9, n. 1, p. 1, 2012. Disponível em: https://revistas.ufg.br/REF/article/view/21950. Acesso em: 28 maio. 2022.

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