CM004 Evaluation of chiral stationary phases in the separation of the enantiomers of fexofenadine

Autores

  • Gisele Maria Metta
  • Anderson Rodrigo Moraes de Oliveira

Resumo

Fexofenadine is commercially available as a racemic mixture of two pharmacologically active enantiomers and it can be found under the trade name Allegra® D. Studies have shown that the pharmacokinetics of fexofenadine is enantioselective with a plasma concentration of R-fexofenadine greater than the S-isomer. In the literature, there are only a few reports of enantioselective separation of fexofenadine using HPLC columns based on cyclodextrins.

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Publicado

28-12-2012

Como Citar

Metta, G. M., & de Oliveira, A. R. M. (2012). CM004 Evaluation of chiral stationary phases in the separation of the enantiomers of fexofenadine. Revista Eletrônica De Farmácia, 9(1), 1. Recuperado de https://revistas.ufg.br/REF/article/view/21950

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