PNS018 Evaluation of acute toxicity, antioxidant activity, flavonoid quantification and total phenols from the hydroethanolic extract from leaves of Leonotis nepetaefalia.

Resumo

The Leonotis nepetaefolia specie, popularly known as “cordão-de-frade”, belongs to the Lamiaceae family, used in popular medicine for several purposes, although with few scientific studies about its biological activity and chemical composition1. The acute toxicity test aims to verify possible behavioral changes, heaviness and lethality with the exacerbated usage of the extract². Free radicals are produced by several factors by our organism and also provoke a series of bad alterations in its physiological and biochemical state. Under this aspect, it is proven necessary the research of substances with antioxidant activity, capable of neutralizing these radicals, thus, avoiding damaging the system. The DPPH is a radical used in rehearsals capable of evaluating the antioxidant’s capacity. Among the natural compounds capable to reduce the DPPH radical, the flavonoids and the phenols stand out, due to their chemical structure³.