BIO070 Molecular analysis of Dengue Virus Type 1 isolates in Ribeirão Preto in 2011

Resumo

Dengue is the most important mosquito-borne viral disease worldwide. Dengue virus (DENV) is a member of the genus Flavivirus and family Flaviviridae. DENV include four antigenically related viruses named dengue virus type 1 to 4 (DENV 1-4). Each of the four serotypes is able to cause disease with a full spectrum of clinical manifestation. DENV-1 is composed of five genotypes: genotype I is represented by viruses of Taiwan and Thailand; genotype II is represented by viruses of Thailand; genotype III is represented by strains of Malaysia; genotype IV is represented by viruses of Southeast Asia, South Pacific and Australia and genotype V is represented by viruses of America, Africa and Southeast Asia. Considering that Ribeirão Preto is an endemic city for this disease, it is of great importance to monitor the circulating viruses, which would allow the identification of new serotypes or subtypes that could be related to most severe cases of the disease. Phylogenetic analysis also allows a better assessment of the pattern of migration and evolution of these viruses.