BIO030 Stimulus of chitosan-alginate biomembrane in inflammatory phase and on re-epithelialization of skin wounds in rats

Resumo

Chronic wounds require a long treatment time, resulting in high-cost medical care. Therefore, the search for new natural therapeutic healing substances, non-toxic and easy access to population has gained importance in recent years. Chitosan and alginate are well-known for healing properties. Chitosan, a natural cationic polymer, is biologically renewable, biodegradable, biocompatible, non-antigenic, non-toxic, biofunctional, and it can accelerate wound healing process enhancing functions of inflammatory cells, macrophages, and fibroblasts. Alginate, an anionic polymer, also is biocompatible, hydrophilic, and biodegradable under normal physiological conditions. It is able to maintain a physiologically moist microenvironment that promotes healing, the formation of granulation tissue and achieves hemostasis.