FTOX005 Anticonvulsant effects of erythrinian alkaloids from Erythrina mulungu: preliminary evaluation on a chronic animal model basis.

Autores

  • Erica A. Gelfuso
  • Alexandra O.S. Cunha
  • Ana M.S. Pereira
  • Rene O. Beleboni

Resumo

Temporal Lobe Epilepsy (TLE) is responsible for 40% of diagnosed cases of epilepsy. The search of new antiepileptic drugs (AEDs) is of relevance to understanding of this neurological disorder and also for a better treatment of patients. The plant E. mulungu Mart. ex Benth. (Leguminosae-Papilionaceae) has been used in the folk medicine and also in industrial phytoterapical preparations due to its sedative, anticonvulsant, hypnotic and anxiolytic properties. Indeed, recent reports have pointed to a marked anticonvulsant effects of E. mulungu flower and leaf hidroalcoolic extract in different acute animal models of epilepsy. Those anticonvulsant effects have been attributed to (+)-erythravine, (+)-11-?-hidroxi-erythravine and/or erysothrine alkaloids isolated from the plant. However, no experimental approach has been used to evaluate the anticonvulsant effects of these alkaloids in a chronic animal model of epilepsy.

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Publicado

2012-12-27

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GELFUSO, E. A.; CUNHA, A. O.; PEREIRA, A. M.; BELEBONI, R. O. FTOX005 Anticonvulsant effects of erythrinian alkaloids from Erythrina mulungu: preliminary evaluation on a chronic animal model basis. Revista Eletrônica de Farmácia, Goiânia, v. 9, n. 1, p. 1, 2012. Disponível em: https://revistas.ufg.br/REF/article/view/21876. Acesso em: 14 ago. 2022.

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