TFC024 Development of nanoemulsions containing ursolic acid: optimizing the emulsification temperature

Autores

  • Erika Cristina Vargas de Oliveira
  • Josimar de Oliveira Eloy
  • Juliana Palma Abriata Barcellos
  • Trevisani Garcia Trevisani
  • Juliana Maldonado Marchetti

Resumo

Ursolic acid (UA), a triterpenoid, has potent anti-inflammatory, anti-cancer and trypanocidal activity being a promising drug to treat Chagas disease but its clinical use is limited by its poor aqueous solubility which compromises its efficacy for delivery and absorption. One of the strategies to overcome this limitation is the use of nanoemulsions (NE). Recently, increasing attention has been focused on this drug delivery system due to their ease of formulation with biocompatible excipients, and unique properties such as smaller droplet size (<200nm), increasing solubility and dissolution rate, improving diffusion and mucosal permeability.

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Publicado

2012-12-27

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DE OLIVEIRA, E. C. V.; ELOY, J. de O.; BARCELLOS, J. P. A.; TREVISANI, T. G.; MARCHETTI, J. M. TFC024 Development of nanoemulsions containing ursolic acid: optimizing the emulsification temperature. Revista Eletrônica de Farmácia, Goiânia, v. 9, n. 1, p. 1, 2012. Disponível em: https://revistas.ufg.br/REF/article/view/21850. Acesso em: 19 maio. 2022.

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